Breaking Bone News!

During the course of my work day, I will review and report a large number of chest, spine, or extremity x-rays taken on postmenopausal women with low bone density or osteoporosis.

While catching up on journal reading, I came across some exciting research news for women with osteoporosis.

Published in the New England Journal of Medicine, a phase 2 trial performed by Amgen and UCB showed that compared to placebo, Romosozumab treatment for 12 months increased bone density at the lumbar spine, total hip and femoral neck.

Significant increases were noted in the first BMD test at three-month follow-up. The lumbar spine and hip bone density values were significantly greater than those observed with other treatments such as Fosamax and Forteo.
At the end of 12 months of treatment, increase in bone density was 11.3% for Romosozumab at the lumbar spine compared to 4.1% and 7.1% with Fosamax (alendronate) and Forteo (teriperatide). At the total hip, romosozumab treatment increased BMD 4.1 percent, while documented increases with FOSAMAX (alendronate) were 1.9 percent and with FORTEO (teriperatide) were 1.3 percent (all p<0.001). Romosozumab is one of the few drugs that stimulates bone formation and reduces bone destruction. It builds bone by inhibiting a protein called sclerostin. Approximately 50% of all women over age 50 will have an osteoporosis-related fracture in their remaining lifetime. According to the National Osteoporosis Foundation, those individuals who have had a hip fracture are at a four-times greater risk of a second hip fracture. Bone fractures secondary to osteoporosis is very common in postmenopausal women and have a significant impact on the patient, their family and the healthcare system. The World Health Organization has officially declared osteoporosis a public health crisis, while the International Osteoporosis Foundation urges governments worldwide to make osteoporosis a healthcare priority. For more detailed information on how to maintain healthy bone go to the Store section and download, Better Health Better Bones. Your Guide to Osteoporosis. Source: Amgen.com

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