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Ovarian Cancer Facts You Should Know: Ovarian cancer forms in ovarian tissues. Most ovarian cancers are either ovarian cancer that begins in the cells on the surface of the ovary ( epithelial carcinomas) or cancer that begins in egg cells (malignant germ cell tumors). How often does Ovarian Cancer occur?: It is the fifth leading cause of cancer-related death among women in the United States and accounts for approximately 3 percent of all cancers in women. The rate of ovarian cancer has been dropping since the mid-1980s. It occurs more often in white women than women of other racial/ethnic groups. Ovarian cancer has the highest death rate of all cancers of the female reproductive system. This is partly due to