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Estrogen Works in the Brain to Keep Weight in Check From (HealthNewsDigest.com) – DALLAS – Oct. 20, 2011 – A recent UT Southwestern Medical Center study found that estrogen regulates energy expenditure, appetite and body weight, while insufficient estrogen receptors in specific parts of the brain may lead to obesity. “Estrogen has a profound effect on metabolism,” said Dr. Deborah Clegg, associate professor of internal medicine and senior author of the study published Oct. 5 in Cell Metabolism. “We hadn’t previously thought of sex hormones as being critical regulators of food intake and body weight.” The mouse study is the first to show that estrogen, acting through two hypothalamic neural centers in the brain, keeps female body weight in check